Cause Hyper IgM syndrome

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class switch recombination


different genetic defects cause higm syndrome, vast majority inherited x-linked recessive genetic trait , sufferers male.


igm form of antibody b cells produce initially, before undergo class switching due exposure recognized antigen. healthy b cells efficiently switch other types of antibodies needed attack invading bacteria, viruses, , other pathogens. in people hyper igm syndromes, b cells keep making igm antibodies because can t switch different antibody. results in overproduction of igm antibodies , underproduction of iga, igg, , ige.








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