Pathophysiology Von Willebrand disease

-


von willebrand factor active in conditions of high blood flow , shear stress. deficiency of vwf, therefore, shows in organs extensive small vessels, such skin, gastrointestinal tract, , uterus. in angiodysplasia, form of telangiectasia of colon, shear stress higher in average capillaries, , risk of bleeding increased concomitantly.


vwf carries factor vii (fviii), stimulates start of clotting process. typically, individual experience decreased levels of both vwf , fviii.


in more severe cases of type 1 vwd, genetic changes common within vwf gene , highly penetrant. in milder cases of type 1 vwd, complex spectrum of molecular pathology may exist in addition polymorphisms of vwf gene alone. individual s abo blood group can influence presentation , pathology of vwd. individuals blood group o have lower mean level individuals other blood groups. unless abo group–specific vwf:antigen reference ranges used, normal group o individuals can diagnosed type vwd, , individuals of blood group ab genetic defect of vwf may have diagnosis overlooked because vwf levels elevated due blood group.








Comments

Post a Comment

Popular posts from this blog

Prosodic bootstrapping Bootstrapping (linguistics)

-
1 prosodic bootstrapping 1.1 prosodic cues syntactic structure 1.2 prosodic cues clauses , phrases 1.3 criticism prosodic bootstrapping even before infants can comprehend word meaning, prosodic details assist them in discovering syntactic boundaries. prosodic bootstrapping or phonological bootstrapping investigates how prosodic information — includes stress, rhythm, intonation, pitch, pausing, dialectal features — can assist child in discovering grammatical structure of language or acquiring. in general, prosody introduces features reflect either attributes of speaker or of utterance type. speaker attributes include emotional state, presence of irony or sarcasm. utterance-level attributes used mark questions, statements, , commands, , can used mark contrast. prosodic features associated speaker: emotional state, irony, sarcasm prosodic features associate utterance type: question, statement, command, contrast similarly, in sign language, prosody includes facial expression, mouthing, , r...
Read more

Principal leitmotifs Music of The Lord of the Rings film series

-
1 principal leitmotifs 1.1 first appearance in fellowship of ring 1.2 first appearance in 2 towers 1.3 first appearance in return of king 1.4 reprised themes hobbit 1.5 themes of hobbit principal leitmotifs howard shore s composition not carry motifs on either other scores of career or passages of existing film or stage music, exception of 1 intentional nod richard wagner on end-credits of third film. shore wrote long series of interrelated leitmotifs used, developed, combined or fragmented throughout 3 scores. motifs attached places, cultures, characters, objects , occurrences. while stage , film composers deviated meaning of themes , used them romantically (i.e. suggestion of mood) shore refrains using technique. several pieces feature intriguing thematic choices choosing history of 1 ring theme passage of argonath or ringwraith theme orc armies in prologue (and again azog in hobbit) neither outright romantic in application , can explained. history of ring being main theme o...
Read more

List of masters Devon and Somerset Staghounds

-
1 list of masters 1.1 north devon staghounds 1.2 chichester s hounds 1.3 devon , somerset staghounds list of masters hugh pollard , master in 1598. (sir hugh ii pollard of king s nympton, father of sir lewis pollard, 1st baronet (c. 1578–c.  1645)) edward ii dyke (d. 1746), portrait circa 1741 attributed thomas hudson (1701–1779), national trust, collection of dunster castle edward dyke (d. 1746), of pixton, in somerset, (eldest brother of thomas dyke (d. 1745) of tetton , of john dyke (d. 1732) of holnicote, in somerset), warden , lesee of royal forest of exmoor , master of staghounds, office held warder. married margaret trevelyan, daughter of sir john trevelyan, 2nd baronet (1670–1755), of nettlecombe in somerset, , widow of alexander luttrell (1705–1737) of dunster castle. edward inherited holnicote , estates in bampton brother john dyke (d. 1732), died without progeny. died without progeny , bequeathed pixton , holnicote niece elizabeth dyke (d. 1753), whom appointed sole executo...
Read more