Signs and symptoms Hirschsprung's disease

a: plain abdominal radiograph showing partz @ rectosigmoid, arrow. b: plain abdominal radiograph showing partz @ midsigmoid, arrow. c: plain abdominal radiograph showing partz @ descending colon, arrow. d: contrast enema showing cetz @ rectosigmoid, arrow. e: contrast enema showing cetz @ midsigmoid, arrow. f: contrast enema showing cetz @ descending colon, arrow.

typically, hirschsprung s disease diagnosed shortly after birth, although may develop adulthood, because of presence of megacolon, or because baby fails pass first stool (meconium) within 48 hours of delivery. normally, 90% of babies pass first meconium within 24 hours, , 99% within 48 hours. other symptoms include green or brown vomit, explosive stools after doctor inserts finger rectum, swelling of abdomen, excessive gas, , bloody diarrhea.

some cases diagnosed later, childhood, before age 10. child may experience fecal retention, constipation, or abdominal distention. incidence of 1 in 5,000 births, cited feature absence of ganglion cells: notably in males, 75% have none in end of colon (rectosigmoid) , 8% lack ganglion cells in entire colon. enlarged section of bowel found proximally, while narrowed, aganglionic section found distally, closer end of bowel. absence of ganglion cells results in persistent overstimulation of nerves in affected region, resulting in contraction.

in extremely rare cases, absence of ganglion cells continues spread after corrective surgery, resulting in multiple surgeries.

those patients have thyroid cancer may able digest food properly, may not able use nutrients properly.